This model is inspired by work published by Avi Peled in his 1998 article titled, "Multiple constraint organization in the brain: A theory for schizophrenia". "The hierarchical organization of the brain can be schematized as a centrifugal arrangement from transmodal to more unimodal systems and regions."---Avi Paled Layered Constraint Model for Schizophrenia| | Constraint | Brocha Area | Region Name | Region Function | | | 4: Transmodal Association | 11,12,13 | caudal orbito-frontal cortex | | | | | 14-16 | insula | | | | | 38 | temporal pole | | | | | 27,28,35 | hippocampal system | | | | | 23-26 | retrosplenial cingulate | | | | | 29-33 | paraolfactory regions | | | | 3: Multimodal Association | 7 | prefrontal cortex | | | | | 39-40 | posterior parietal cortex | | | | | 21,37 | lateral temporal cortex | | | | | 35-36 | parahippocampal gyrus | | | | 2: Unimodal Association | 18-19 | peristriate connections | visual | | | | 20-21 | inferotemporal regions and middle temporal regions | visual | | | | 22 | superior (and dorsal part of) temporal cortex | auditory | | | | 6,8 | premotor regions | motor | | | 1: Primary Sensory-Motor | 17 | Striat or Calcarian Cortex | visual | | | | 41, 42 | Heschel Gyrus on floor of Sylvian cistern | auditory | | | | 3b | Anterior flank of postcentral gyrus | somatosensory | | | | 43 | Fronto-insular junction | gustatory | | | | 4, 6 | Precentral gyrus | motor |
Constraint Failure Types| | Constraint Failure Type | Description | | | 1: Disorganization | "Disorganized constraint breakdown involves most if not all of the brain areas." | | | 2: Reality-Distortion | "Auditory unimodel and their connections with heteromodal networks are primarily affected. Delusions are related to higher transmodal systems that involve semantic conceptual processes of ideas." | | | 3: Poverty | "Poverty symptoms presumably emerge from constraint breakdown of the networks located in the highest level of the hierarchy. These are the networks that connect sensation with action." |
|
